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Beyond Audibility – Diverse Cochlear Pathophysiology Profiles in SNHL, presented in partnership with the University of Pittsburgh

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1.  What is cochlear synaptopathy primarily associated with? Exposure to intense sounds and normal aging Genetic mutations Infections in the middle ear Ear pain

2.  Which of the following diagnostic tools is likely to be useful for detecting cochlear synaptopathy? Pure-tone audiometry Tympanometry Otoacoustic emissions testing Auditory brainstem response (ABR) testing

3.  Which cochlear pathology is associated with distorted tonotopy? Damage of inner hair-cell stereocilia Damage of outer hair cells Cochlear synaptopathy Decrease in endocochlear potential

4.  What is a direct functional consequence of distorted tonotopy? Masking of high-frequency speech content by low-frequency noise energy Masking of low-frequency speech content by high-frequency noise energy Reduced phase locking to low-frequency speech content Increased phase locking to low-frequency speech content

5.  What is a potential application of diagnostic tools that can identify the specific cochlear pathology underlying sensorineural hearing loss in an individual patient? Evaluating candidacy for emerging pharmacological interventions Serving as end points to test the efficacy of emerging pharmacological interventions in clinical trials Further tailoring of signal processing algorithms and amplification prescriptions to individual patients All of the above