Exam Preview

Moving Closer to Universal CMV (Cytomegalovirus) Newborn Screening

---

1.  Hearing loss is the most common sequelae of congential CMV. What elements of hearing loss should have ongoing monitoring? Degree, type ( conductive vs SNHL), onset, and fluctuation Degree, onset, fluctuation, progression and age of idenfication Onset, unilateral vs bilateral presentation, type of hearing loss Age of identification, type, unilateral vs bilateral

2.  A key factor of CMV screening is: Screening must be completed before 21 days of life Screening after 21 days of life is preferred It doesn’t matter when the sample is obtained as long as the child is symptomatic Only symptomatic children should be screened

3.  The highest viral load of CMV is presented in which type of screen? Saliva Urine Dried Blood Spot (DBS) All of them are the same

4.  What are the four classification of congenital CMV infections? Symptomatic unidentified, asymptomatic in remission, moderate symptoms, no symptoms Symptomatic, Asymptomatic, Unknown, Not identified Symptomatic congenital CMV, mild symptomatic congenital CMV, Asymptomatic congenital CMV with isolated SNHL, Asymptomatic congenital CMV Symptomatic CMV with bilateral hearing loss, Asymptomatic congenital CMV with progressive hearing loss, Symptomatic CMV with normal hearing, Severe symptomatic congenital CMV

5.  Infants with symptomatic congenital CMV should have the following evaluations at birth? Hearing testing and physical exam Hearing testing, physician exam and opthalmolgic examination Hearing testing, physician exam, blood work and opthalmolic examination Thorough physical exam, blood work, Neuroimaging, Opthalmologic examination and hearing testing every 6 months until age 3.

6.  Approximately how many infants are born with congenital CMV in the US every years? 10,000 20,000 45,000 less than 5,000

7.  What classification of infants are recommended to be treated with ganciclovir/valganciclovir? All symptomatic infants All symptomatic and asymptomatic infants Only those infants with confirmed hearing loss Only symptomatic congenital CMV infants that present with moderate to severe sequelae

8.  The incidence of congenital CMV infection at birth resulting in hearing loss is? 21% 14% 30% 3%

9.  What is the sensitivity and specificity of liquid saliva PCR assay? 25% sensitivity/ 25% specificity 50% sensitivity/50% specificity 100% sensitivity/99.9% specificity 80% sensitivity/100% specificity

10.  How does a Targeted Screening approach differ from Universal Newborn CMV screening A targeted approach performs CMV screening on all infants who refer on the newborn hearing screening A targeted approach will miss infants who have congenital CMV but Pass their newborn hearing screening A targeted approach only targets mothers who have reported family history of hearing impairment A and B