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20Q: Auditory Biotechnologies - Finding Their Way to the Clinic

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1.  What are some examples of auditory biotechnologies currently being researched for the treatment of sensorineural hearing loss, and what are the specific cellular deficits associated with the degree of hearing loss that these technologies aim to address?
  1. Cochlear implants and hair cell regeneration, targeting the loss of inner and outer hair cells
  2. Otoprotective agents to be delivered along with ototoxic agents, protecting against damage to structures of the inner ear
  3. Spiral ganglion neuron regeneration and axonal outgrowth, targeting the loss of spiral ganglion neurons
  4. All of the above
2.  Which of the following is being considered as a potential strategy to stimulate hair cell regeneration in the inner ear?
  1. Gene therapy
  2. Small molecules and drug-like molecules
  3. Stem cells and other biomaterials
  4. All of the above
3.  Which statement presents the most accurate role of Atoh1 during hair cell regeneration?
  1. Atoh1 can be used exclusively to drive optimal hair cell regeneration outcomes
  2. Atoh1 is a transcription factor that regulates other genes and interacts with other signaling pathways during hair cell regeneration, and ultimately promotes the likelihood of hair cell differentiation
  3. Notch and other signaling pathways do not interact with Atoh1
  4. Changing Atoh1 expression typically has no effect on hair cell regeneration
4.  Which of the following statements is true about Decibel Therapeutics' DB-020 treatment?
  1. DB-020 is a restorative therapy for hearing loss.
  2. DB-020 is administered via oral medication.
  3. DB-020 is designed to protect against cisplatin-induced ototoxicity.
  4. DB-020 was ineffective in the double-blind, placebo-controlled Phase 1b clinical trial.
5.  Which of the following statements is true about considering the impact of auditory deprivation and neural degeneration?
  1. Regenerative technologies are currently the best option for patients with auditory deprivation.
  2. Patients who receive cochlear implants are guaranteed to have full restoration of hearing.
  3. When managing today’s patients who seek hearing help, it is important to consider not only the psychosocial implications but also the potential neural degeneration that may occur without appropriate intervention.
  4. Patients who receive hearing restoration technologies are guaranteed to have full restoration of hearing.

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