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What is the Post Synaptic Mechanism of ANSD?

James W. Hall III, PhD

October 28, 2013

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Question

Could you go over the post synaptic mechanism of ANSD?

Answer

A post-synaptic form of auditory neuropathy spectrum disorder (ANSD) is dysfunction of the auditory nerve or (theoretically) the synapse between the inner hair cells and the afferent auditory nerve fibers. The term usually means that the nerve is not capable of being effectively activated with electrical stimulation. In some cases, however, the dysfunction is post-synaptic (neural) but the nerve is reasonably intact and simply not capable of responding to stimulation with abrupt and transient sounds (like clicks and perhaps tone bursts). Chuck Berlin coined the term "auditory dys-synchrony" for these patients.

The 1996 article by Starr and colleagues along with the 2008 Guidelines on ANSD provide good explanations of the post-synaptic mechanism.

References

Starr, A., Picton, T.W., Sininger, Y., Hood, L.J., & Berlin C.I. (1996). Auditory neuropathy. Brain, 119, 741-753.

Guidelines for identification and management of infants and young children with auditory neuropathy spectrum disorder. (2008). Available from the Bill Daniels Center for Children’s Hearing, The Children’s Hospital, Colorado, USA and at https://www.childrenscolorado.org/pdf/Guidelines for%20Auditory Neuropathy -%20BDCCH.pdf

This Ask the Expert was asked as a follow up question to Dr. Hall's course, Clinical Applications of Electrocochleography Today, which can be accessed in the AudiologyOnline Course Library.


james w hall iii

James W. Hall III, PhD

James W. Hall III, PhD is an internationally recognized audiologist with 40-years of clinical, teaching, research, and administrative experience. He received his Ph.D. in audiology from Baylor College of Medicine under the direction of James Jerger.  During his career, Dr. Hall has held clinical and academic audiology positions at major medical centers. Dr. Hall now holds appointments as Professor at Salus University and the University of Hawaii, and as Extraordinary Professor at the University of Pretoria South Africa. Dr. Hall is the author of over 160 peer-reviewed journal articles, monographs, or book chapters, and nine textbooks including the 2014 Introduction to Audiology Today and the 2015 eHandbook of Auditory Evoked Responses.

 


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