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Pharmacology Primer for the Audiology Practitioner

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1.  Which of the following routes of administration has 100% bioavailability all of the time? PO rectal topical IV

2.  Metabolism or biotransformation does not occur via which organs or organ systems? Liver Heart Kidney Lungs

3.  Elimination routes of a drug do not include: urine plasma bile feces

4.  The most important factor in determining drug concentrations is: Route Absorption Clearance Gender

5.  Aminoglycoside antimicrobials may cause toxicity in which organs or tissues? bone marrow and inner ear liver and inner ear lungs and inner ear kidney and inner ear

6.  Monitoring the _____ level with aminoglycosides helps to diminish or eliminate the potential ototoxicity. Trough Peak Endolymph Perilymph

7.  The "oto-irritating" potential of aspirin is most likely due to the fact that it is structurally a _______. NSAID Salicylate Chemical Chelator

8.  The most common ototoxic compound in clinical use is: Cisplatin Acetaminophen Furosemide Creatinine

9.  Which of the following is a risk factor for increasing ototoxicty of a loop diuretic like furosemide? Decreasing the rate on infusion. Using it with vancomycin. Using it for a patient with decreased renal function. All of the above

10.  All of the following are risk factors for cisplatin ototoxicity EXCEPT: Using it in a patient who has renal impairment. Using it in a patient who has had cranial irradiation. Using it in a patient who is using gentamicin for an infection. Using it in a patient who is 32 years old with no prior medical history or concurrent medications.