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Monitoring for Ototoxicity with OAEs

Kathleen C. M. Campbell, PhD

November 8, 2004

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Question

How often should OAE testing be done to monitor for ototoxicity, and when should you stop testing?

Answer

Basically, OAE monitoring should be performed at the same time intervals as for other ototoxicity monitoring protocols. For aminoglycosides that is generally once or preferably twice a week. For cisplatin it is generally just before each round of chemotherapy. Naturally a baseline evaluation is essential for all testing as tests must be interpreted relative to baseline. Because cisplatin and aminoglycosides may cause delayed or progressive hearing loss, a follow-up test should be performed 4-6 months after drug discontinuation. If it can be arranged at monthly intervals during that time period, that would be optimal.

TOAES, DPOAEs, and high frequency audiometry all have been demonstrated to show ototoxic changes prior to changes in the conventional pure-tone frequency test range of 8000 Hz and below. Currently high frequency audiometry is the "Gold Standard" because we have well established and published criteria for significant change that have been demonstrated to have excellent specificity and sensitivity. However several researchers are investigating different types of OAE protocols and significant change criteria for OAEs so they may be available in the not too distant future. "

Kathleen C.M. Campbell, PhD, is Professor and Director of Audiology Research at Southern Illinois University School of Medicine. She has been doing research in ototoxicity for over 15 years and has had several NIH and pharmaceutical company grants for her research in that area. She holds two patents for pharmaceutical agents to prevent and rescue from ototoxicity and has several others in prosecution.


kathleen c m campbell

Kathleen C. M. Campbell, PhD

Professor and Director of Audiology Research - Southern Illinois University School of Medicine

Kathleen Campbell, Ph.D., Professor and Director of Audiology Research at
SIU School of Medicine served on the AAA Board of Directors, received an AAA Presidential Citation, a Medical Innovators Award and is an ASHA fellow. She authored Essential Audiology for Physicians and edited/authored Pharmacology and Ototoxicity for Audiologists. She has received a number of grants from NIH and other agencies for her research in otoprotective agents and is the inventor of the protective agent D-methionine patents. She serves on the NIH/NCI CTCAE Community Based Committee: Advisory Committee for CTCAE Guidelines She also serves on two SIOP International Society of Pediatric Oncology:Committees: Otoprotective Agents for Ototoxicity. and Animal Models for Ototoxicity.


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