Question
How often should OAE testing be done to monitor for ototoxicity, and when should you stop testing?
Answer
Basically, OAE monitoring should be performed at the same time intervals as for other ototoxicity monitoring protocols. For aminoglycosides that is generally once or preferably twice a week. For cisplatin it is generally just before each round of chemotherapy. Naturally a baseline evaluation is essential for all testing as tests must be interpreted relative to baseline. Because cisplatin and aminoglycosides may cause delayed or progressive hearing loss, a follow-up test should be performed 4-6 months after drug discontinuation. If it can be arranged at monthly intervals during that time period, that would be optimal.
TOAES, DPOAEs, and high frequency audiometry all have been demonstrated to show ototoxic changes prior to changes in the conventional pure-tone frequency test range of 8000 Hz and below. Currently high frequency audiometry is the "Gold Standard" because we have well established and published criteria for significant change that have been demonstrated to have excellent specificity and sensitivity. However several researchers are investigating different types of OAE protocols and significant change criteria for OAEs so they may be available in the not too distant future. "
Kathleen C.M. Campbell, PhD, is Professor and Director of Audiology Research at Southern Illinois University School of Medicine. She has been doing research in ototoxicity for over 15 years and has had several NIH and pharmaceutical company grants for her research in that area. She holds two patents for pharmaceutical agents to prevent and rescue from ototoxicity and has several others in prosecution.
Kathleen C. M. Campbell, PhD
Professor and Director of Audiology Research - Southern Illinois University School of Medicine
Kathleen Campbell, Ph.D., Professor and Director of Audiology Research at SIU School of Medicine served on the AAA Board of Directors, received an AAA Presidential Citation, a Medical Innovators Award and is an ASHA fellow. She authored Essential Audiology for Physicians and edited/authored Pharmacology and Ototoxicity for Audiologists. She has received a number of grants from NIH and other agencies for her research in otoprotective agents and is the inventor of the protective agent D-methionine patents. She serves on the NIH/NCI CTCAE Community Based Committee: Advisory Committee for CTCAE Guidelines She also serves on two SIOP International Society of Pediatric Oncology:Committees: Otoprotective Agents for Ototoxicity. and Animal Models for Ototoxicity.
Related Courses
1https://www.audiologyonline.com/audiology-ceus/course/20q-ototoxicity-and-audiology-insights-3566520Q: Ototoxicity and Audiology - Insights from an InnovatorAn insider's look at key highlights and challenges of ototoxicity research over the years and a discussion of exciting emerging studies to watch for, written in an engaging Q & A format with distinguished audiology innovator, Kathleen Campbell, PhD.textual, visual
An insider's look at key highlights and challenges of ototoxicity research over the years and a discussion of exciting emerging studies to watch for, written in an engaging Q & A format with distinguished audiology innovator, Kathleen Campbell, PhD.
2https://www.audiologyonline.com/audiology-ceus/course/common-errors-in-diagnostic-audiology-30162Common Errors in Diagnostic Audiology: Tips for Improving Efficiency, Accuracy and OutcomesThis practical 3-part course series reviews standard diagnostic audiology procedures and the common errors that can lead to clinical inefficiency and inaccurate results. Easy to implement guidance is provided for cleaning up clinical protocols to ensure that audiological testing yields the highest quality information in a cost-efficient manner for an accurate diagnosis and improved patient outcomes.auditory, textual, visual
This practical 3-part course series reviews standard diagnostic audiology procedures and the common errors that can lead to clinical inefficiency and inaccurate results. Easy to implement guidance is provided for cleaning up clinical protocols to ensure that audiological testing yields the highest quality information in a cost-efficient manner for an accurate diagnosis and improved patient outcomes.
3https://www.audiologyonline.com/audiology-ceus/course/empowerment-and-behavioral-insights-in-37124Empowerment and Behavioral Insights in Client Decision Making, presented in partnership with NALBehavioral Insights can be used to understand and support hearing health decision-making, particularly in the appointment setting. An overview of empowering the individual's first awareness of hearing loss to hearing aid fitting and then to becoming an active hearing aid user will be covered.auditory, textual, visual
Behavioral Insights can be used to understand and support hearing health decision-making, particularly in the appointment setting. An overview of empowering the individual's first awareness of hearing loss to hearing aid fitting and then to becoming an active hearing aid user will be covered.
4https://www.audiologyonline.com/audiology-ceus/course/cognition-and-audition-supporting-evidence-37381Cognition and Audition: Supporting Evidence, Screening Options, and Clinical ResearchThe evidence supporting the connection between cognitive health and hearing performance continues to expand, further supporting the need for a cognitive screening tool as part of an audiology clinical practice. This course will provide guidance on cognitive screening options, the benefits and challenges of each, evidence to support the use of each tool, and current clinical research that is underway exploring new technologies, implementation, and clinical outcomes.auditory, textual, visual
The evidence supporting the connection between cognitive health and hearing performance continues to expand, further supporting the need for a cognitive screening tool as part of an audiology clinical practice. This course will provide guidance on cognitive screening options, the benefits and challenges of each, evidence to support the use of each tool, and current clinical research that is underway exploring new technologies, implementation, and clinical outcomes.
5https://www.audiologyonline.com/audiology-ceus/course/innovative-audiologic-care-delivery-38661Innovative Audiologic Care DeliveryThis four-course series highlights the next generation of audiology innovators and their pioneering approaches to meeting unmet audiologic needs in their communities and beyond. This peer-to-peer educational series highlights researchers, clinicians, and business owners and their pioneering ideas, care delivery models, and technologies which provide desperately needed niche services and audiologic care.auditory, textual, visual
'I enjoyed these 4 courses in the series more than any courses I've ever done on Audiology Online!!! Excellent information very well presented with great handouts and study references!!! Kudos to all the presenters and AO!!!'Read Reviews
This four-course series highlights the next generation of audiology innovators and their pioneering approaches to meeting unmet audiologic needs in their communities and beyond. This peer-to-peer educational series highlights researchers, clinicians, and business owners and their pioneering ideas, care delivery models, and technologies which provide desperately needed niche services and audiologic care.
